Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | PNMT | P11086 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23306037 | 1.00 | DRD2 (0.45) | DRD2DRD4DRD3CYP2C8CYP2C9 | |
| SCHEMBL2876799 | 0.85 | PNMT (0.49) | ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL13950761 | 0.83 | CYP2C8 (0.42) | CYP2C8CYP2C9KCNH2CYP2B6ADRA2A | |
| SCHEMBL29113500 | 0.82 | DRD2 (0.48) | DRD2DRD3CYP2C8CYP2C9KCNH2 | |
| SCHEMBL20909682 | 0.81 | DRD2 (0.46) | DRD2DRD4DRD3HTR1DHTR1B | |
| SCHEMBL12778356 | 0.80 | CYP2C8 (0.41) | CYP2C8CYP2C9KCNH2CYP2B6ADRA2A | |
| SCHEMBL2086346 | 0.80 | CYP2C8 (0.41) | CYP2C8CYP2C9KCNH2CYP2B6ADRA2A | |
| SCHEMBL6839556 | 0.79 | CA1 (0.62) | DRD2DRD4DRD3HTR1DHTR1B | |
| SCHEMBL20722746 | 0.78 | CA1 (0.50) | CYP2C8CYP2C9KCNH2CYP2B6ADRA2A | |
| SCHEMBL20722885 | 0.78 | CA1 (0.50) | CYP2C8CYP2C9KCNH2CYP2B6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396300-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092153-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI-AVENTIS (FR) | 2010-08-19 | — | — | WO | disclosed |