Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27870348 | 0.84 | PTGS2 (0.39) | PTGS2JAK1JAK3JAK2MAPK10 | |
| Hydrochloric Acid SCHEMBL2807566 | 0.84 | PTGS2 (0.38) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL27870363 | 0.83 | PTGS2 (0.42) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL2782296 | 0.80 | PTGS2 (0.44) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL2811243 | 0.80 | BDKRB1 (0.40) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL14856644 | 0.80 | PTGS2 (0.39) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL2808238 | 0.78 | BDKRB1 (0.47) | PTGS2 | |
| SCHEMBL2800931 | 0.78 | JAK1 (0.46) | PTGS2JAK1JAK3JAK2MAPK10 | |
| Hydrochloric Acid SCHEMBL184840 | 0.77 | JAK1 (0.46) | PTGS2JAK1JAK3JAK2MAPK10 | |
| SCHEMBL2806873 | 0.75 | BDKRB1 (0.37) | PTGS2JAK1JAK3JAK2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102414177-A | Compounds as bradykinin b1 antagonists | BOEHRINGER INGELHEIM INT | 2012-04-11 | — | — | CN | disclosed |