Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL184840 | 0.99 | JAK1 (0.46) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL2782296 | 0.88 | PTGS2 (0.44) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL2809975 | 0.81 | PTGS2 (0.37) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL2809973 | 0.81 | PTGS2 (0.37) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL27870347 | 0.78 | PTGS2 (0.44) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL185749 | 0.78 | PTGS2 (0.40) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL2784614 | 0.77 | JAK1 (0.43) | JAK1JAK3JAK2PTGS2MAPK10 | |
| Hydrochloric Acid SCHEMBL2811611 | 0.77 | PTGS2 (0.39) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL2808119 | 0.75 | JAK1 (0.39) | JAK1JAK3JAK2PTGS2MAPK10 | |
| SCHEMBL186439 | 0.75 | TDO2 (0.40) | JAK1JAK3JAK2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |