SCHEMBL27870534

SCHEMBL27870534

COC(=O)C(CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1)N1CCN(S(C)(=O)=O)CC1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ADAM17 P78536 14/20 0.66
ADAM33 Q9BZ11 5/20 0.65
MMP1 P03956 2/20 0.59
MMP3 P08254 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27977398 1.00 ADAM17 (0.66) ADAM17ADAM33MMP1MMP3
SCHEMBL27977673 1.00 ADAM17 (0.66) ADAM17ADAM33MMP1MMP3
SCHEMBL996063 0.92 ADAM17 (0.69) ADAM17ADAM33MMP1MMP3
SCHEMBL995162 0.92 ADAM17 (0.69) ADAM17ADAM33MMP1MMP3
SCHEMBL995164 0.92 ADAM17 (0.69) ADAM17ADAM33MMP1MMP3
SCHEMBL2680791 0.90 ADAM33 (0.78) ADAM17ADAM33MMP1MMP3
SCHEMBL2680798 0.90 ADAM33 (0.78) ADAM17ADAM33MMP1MMP3
SCHEMBL995156 0.90 ADAM33 (0.81) ADAM17ADAM33MMP1MMP3
SCHEMBL995157 0.90 ADAM33 (0.81) ADAM17ADAM33MMP1MMP3
SCHEMBL2680630 0.89 ADAM33 (0.79) ADAM17ADAM33MMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102471260-B Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics GALDERMA RESEARCH & DEVELOPMENT (FR) 2014-10-22 CN disclosed
CN-102471260-A Novel benzenesulfonamide compounds, process for their synthesis and their use in pharmaceuticals and cosmetics GALDERMA RES & DEV 2012-05-23 CN disclosed