Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640964 | 0.85 | MAPK14 (0.59) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| Ammonia Solution, Strong SCHEMBL27870854 | 0.84 | TGFBR1 (0.62) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12727178 | 0.83 | TGFBR1 (0.55) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7168832 | 0.76 | MAPK14 (0.63) | MAPK14 | |
| SCHEMBL1639277 | 0.76 | GPR119 (0.50) | TGFBR1MAPK14EGFR | |
| SCHEMBL6955184 | 0.76 | MAPK14 (0.62) | MAPK14 | |
| SCHEMBL6951373 | 0.76 | MAPK14 (0.66) | MAPK14 | |
| SCHEMBL23410405 | 0.75 | MAPK14 (0.49) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6949291 | 0.75 | TGFBR1 (0.42) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6943768 | 0.75 | MAPK14 (0.62) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102686580-A | Imidazole derivatives as casein kinase inhibitors | PFIZER | 2012-09-19 | — | — | CN | disclosed |