Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9659950 | 0.89 | KDM4E (0.47) | LMNATSHRCYP2C19SLC22A2SLC22A1 | |
| SCHEMBL5939832 | 0.85 | POLB (0.51) | LMNACYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL28795018 | 0.81 | CACNA1B (0.50) | ALDH1A1MAPTHIF1AMEN1KMT2A | |
| SCHEMBL5940572 | 0.79 | HTT (0.52) | LMNATSHRCYP2C19SLC22A2SLC22A1 | |
| SCHEMBL22987140 | 0.77 | KDM4E (0.49) | LMNATSHRCYP2C19SLC22A2SLC22A1 | |
| SCHEMBL854187 | 0.74 | LMNA (0.53) | LMNAMAPTKDM4EHIF1ASLC22A6 | |
| SCHEMBL11985612 | 0.74 | EPHX2 (0.46) | LMNATSHRCYP2C19SLC22A2SLC22A1 | |
| SCHEMBL22987109 | 0.74 | NPC1 (0.44) | LMNATSHRCYP2C19SLC22A2SLC22A1 | |
| SCHEMBL6555537 | 0.74 | SMN1; SMN2 (0.52) | LMNAALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL13994618 | 0.73 | POLB (0.58) | LMNACYP2C19ALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102449165-B | Genetic markers for risk management of atrial fibrillation and stroke | DECODE GENETICS EHF | 2014-07-09 | — | — | CN | disclosed |
| CN-102449165-A | Genetic markers for risk management of atrial fibrillation and stroke | DECODE GENETICS EHF | 2012-05-09 | — | — | CN | disclosed |