Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10898094 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL10896464 | 0.82 | HDAC1 (0.54) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL5939832 | 0.82 | POLB (0.51) | SMN1; SMN2HDAC1HDAC6RAB9ANPC1 | |
| SCHEMBL3536058 | 0.81 | HDAC1 (0.56) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL31268672 | 0.77 | HDAC1 (0.62) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL2732281 | 0.77 | HDAC1 (0.62) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL11985607 | 0.76 | HDAC1 (0.52) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL19379990 | 0.75 | HDAC1 (0.55) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| SCHEMBL15638588 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1HDAC1HDAC6THRB | |
| Niacin SCHEMBL31228985 | 0.75 | ALDH1A1 (0.78) | SMN1; SMN2HDAC1HDAC6THRBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927030-B1 | USE OF ARYL N-SUBSTITUTED CARBOXAMIDES TO KILL TUMORS | OXIGENE INC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-0927030-A4 | USE OF ARYL N-SUBSTITUTED CARBOXAMIDES TO KILL TUMORS | OXIGENE INC (US) | 2000-01-26 | — | — | EP | disclosed |
| EP-0927030-A1 | USE OF ARYL N-SUBSTITUTED CARBOXAMIDES TO KILL TUMORS | OXIGENE, INC. (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1997032576-A1 | USE OF ARYL N-SUBSTITUTED CARBOXAMIDES TO KILL TUMORS | OXIGENE, INC. (US) | 1997-09-12 | — | — | WO | disclosed |