Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adefovir Dipivoxil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 3/20 | 0.88 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.88 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.88 |
| ▸ | POLA1 | P09884 | 1/20 | 0.88 |
| ▸ | POLG | P54098 | 1/20 | 0.88 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adefovir Dipivoxil SCHEMBL29372789 | 0.94 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL5845498 | 0.94 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL29729 | 0.94 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL3719079 | 0.93 | FAP (0.98) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL3646944 | 0.93 | FAP (0.98) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL3745803 | 0.91 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL457147 | 0.91 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL12391572 | 0.91 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL13239804 | 0.87 | FAP (0.87) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL12391569 | 0.86 | SLC22A6 (0.84) | FAPSLC22A6ABCB11POLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120074-A2 | METHOD FOR PREPARING CRYSTALLINE ADEFOVIR DIPIVOXIL AND ADEFOVIR DIPIVOXIL BUTANOLATE USED THEREIN | HANMI PHARM. CO., LTD. (KR) | 2010-10-21 | — | — | WO | disclosed |