Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adefovir Dipivoxil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 3/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | POLA1 | P09884 | 1/20 | 0.98 |
| ▸ | POLG | P54098 | 1/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.61 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.46 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adefovir Dipivoxil SCHEMBL3646944 | 1.00 | FAP (0.98) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL5845498 | 0.99 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL29729 | 0.99 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL29372789 | 0.99 | FAP (1.00) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL12391572 | 0.95 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL3745803 | 0.95 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL457147 | 0.95 | FAP (0.93) | FAPSLC22A6ABCB11POLA1POLG | |
| Adefovir Dipivoxil SCHEMBL2787331 | 0.93 | FAP (0.88) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL13239804 | 0.92 | FAP (0.87) | FAPSLC22A6ABCB11POLA1POLG | |
| SCHEMBL12391569 | 0.91 | SLC22A6 (0.84) | FAPSLC22A6ABCB11POLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010110506-A1 | DH-TYPE CRYSTALLINE FORM OF ADEFOVIR DIPIVOXIL, PREPARING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR ANTIVIRAL AGENT COMPRISING THE SAME | DAE HE CHEMICAL CO.,LTD. (KR) | 2010-09-30 | — | — | WO | disclosed |