Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787946 | 0.99 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9AHPGDSGMS2MEN1 | |
| SCHEMBL2785051 | 0.95 | EDNRA (0.39) | SMN1; SMN2RAB9AHPGDSGMS2MEN1 | |
| SCHEMBL2787341 | 0.78 | ALDH1A1 (0.44) | SMN1; SMN2RAB9AHPGDSGMS2MEN1 | |
| SCHEMBL2787949 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9AHPGDSGMS2MEN1 | |
| SCHEMBL2787342 | 0.73 | SGMS2 (0.41) | SGMS2ALDH1A1 | |
| SCHEMBL2771308 | 0.73 | SGMS2 (0.44) | SMN1; SMN2RAB9ASGMS2KMT2AALDH1A1 | |
| SCHEMBL2787950 | 0.72 | SGMS2 (0.42) | SGMS2ALDH1A1 | |
| SCHEMBL2785857 | 0.72 | SGMS2 (0.40) | SGMS2 | |
| SCHEMBL2771311 | 0.70 | SGMS2 (0.43) | SGMS2ALDH1A1 | |
| SCHEMBL2785855 | 0.70 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9AHPGDSGMS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |