Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.65 |
| ▸ | GAA | P10253 | 10/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093445 | 0.85 | RAB9A (0.52) | ALDH1A1GAASMN1; SMN2MAPTKMT2A | |
| SCHEMBL1712579 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL29510654 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL27841455 | 0.84 | GAA (0.51) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL27794204 | 0.84 | GAA (0.51) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL27810279 | 0.81 | GAA (0.49) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL27598327 | 0.79 | GAA (0.47) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL11395282 | 0.79 | ALDH1A1 (1.00) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL11396303 | 0.79 | ALDH1A1 (0.65) | ALDH1A1GAASMN1; SMN2MAPTHPGD | |
| SCHEMBL27870795 | 0.78 | GAA (0.46) | ALDH1A1GAASMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102725291-A | Bicyclic pyridines and analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-10-10 | — | — | CN | disclosed |