Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24691558 | 0.76 | LPAR1 (0.55) | LPAR1MAPTRECQLCA12CA1 | |
| SCHEMBL2787490 | 0.74 | POLB (0.42) | LPAR1MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL2786774 | 0.72 | MAPT (0.43) | MAPTTP53POLBTDP1SMN1; SMN2 | |
| SCHEMBL2786903 | 0.71 | EPHX2 (0.39) | LPAR1RECQLSMN1; SMN2NLRP3 | |
| SCHEMBL2787494 | 0.67 | TP53 (0.40) | LPAR1MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL5852210 | 0.66 | CA12 (0.68) | LPAR1MAPTRECQLCA12CA1 | |
| SCHEMBL24479786 | 0.65 | MAPT (0.74) | MAPTTP53POLBTDP1SMN1; SMN2 | |
| SCHEMBL2784409 | 0.65 | EPHX2 (0.46) | MAPTTDP1 | |
| SCHEMBL2788286 | 0.65 | HIF1A (0.61) | MAPTTP53CA12CA1CA2 | |
| SCHEMBL11004024 | 0.64 | LPAR1 (0.60) | LPAR1MAPTRECQLCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |