Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785339 | 0.81 | HIF1A (0.45) | HIF1ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2768846 | 0.73 | HIF1A (0.64) | HIF1ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2786818 | 0.73 | RAB9A (0.41) | HIF1ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1719786 | 0.68 | RAB9A (1.00) | RAB9ANPC1MAPTSMN1; SMN2TAAR1 | |
| SCHEMBL3633396 | 0.67 | NPC1 (0.84) | RAB9ANPC1MAPTSMN1; SMN2TAAR1 | |
| SCHEMBL2785931 | 0.67 | GHSR (0.47) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL2785316 | 0.67 | TP53 (0.52) | HIF1AMAPTSMN1; SMN2TP53 | |
| SCHEMBL2788190 | 0.66 | SMN1; SMN2 (0.55) | HIF1ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2785576 | 0.66 | SMN1; SMN2 (0.48) | HIF1ARAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL23069083 | 0.65 | RAB9A (0.86) | RAB9ANPC1MAPTSMN1; SMN2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |