Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27876342 | 0.88 | POLB (0.35) | TP53 | |
| SCHEMBL2358445 | 0.86 | MAP3K5 (0.33) | MAP3K5PTAFRHTR2BGRM2 | |
| SCHEMBL1933394 | 0.84 | PCSK9 (0.34) | CYP11B1CYP11B2MAP3K5PTAFRHTR2B | |
| SCHEMBL1933909 | 0.74 | GSK3B (0.44) | CYP11B1CYP11B2MAP3K5PTAFRHTR2B | |
| SCHEMBL1932988 | 0.73 | PCSK9 (0.35) | — | |
| SCHEMBL2315327 | 0.71 | LMNA (0.43) | — | |
| SCHEMBL13580578 | 0.71 | TP53 (0.36) | TP53 | |
| SCHEMBL2320144 | 0.70 | PTGS2 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL2319582 | 0.70 | EED (0.39) | — | |
| SCHEMBL2319229 | 0.69 | LATS1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102711470-A | Novel tricyclic compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |