Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675785 | 0.83 | PRKCI (0.64) | LOXL2CDK8MAPK14PRKCIFGFR1 | |
| SCHEMBL27465664 | 0.81 | LOXL2 (0.47) | LOXL2SYKCDK8MAPK14KARS1 | |
| SCHEMBL27481686 | 0.81 | MAPK14 (0.55) | LOXL2SYKMAPK14 | |
| SCHEMBL27893664 | 0.79 | LOXL2 (0.65) | LOXL2SYKTAAR1CDK8MAPK14 | |
| SCHEMBL2642497 | 0.79 | — | — | |
| SCHEMBL3791745 | 0.79 | LOXL2 (0.60) | LOXL2TAAR1CDK8PLAUFGFR2 | |
| SCHEMBL301749 | 0.78 | PRKCI (0.67) | LOXL2TAAR1CDK8PRKCIFGFR2 | |
| Hydrochloric Acid SCHEMBL31572026 | 0.77 | LOXL2 (0.96) | LOXL2LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL4892257 | 0.77 | LOXL2 (0.96) | LOXL2LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL1413435 | 0.77 | LOXL2 (0.96) | LOXL2LOXLOXL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102770425-A | Indolyl-piperidinylbenzylamines as beta-tryptase inhibitors | SANOFI SA | 2012-11-07 | — | — | CN | disclosed |