Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785859 | 0.85 | KMT2A (0.38) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL2787058 | 0.80 | TP53 (0.46) | SMN1; SMN2TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL2439379 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL2784590 | 0.77 | TP53 (0.40) | SMN1; SMN2TP53LMNAKMT2AMAPT | |
| SCHEMBL2784887 | 0.75 | HIF1A (0.39) | ALDH1A1NPC1HTTLMNAKMT2A | |
| SCHEMBL2438649 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53ALDH1A1HTTKMT2A | |
| SCHEMBL2144487 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL2768041 | 0.73 | ALDH1A1 (0.53) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL2784919 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53RAB9ALMNAMAPT | |
| SCHEMBL2788818 | 0.72 | TP53 (0.51) | SMN1; SMN2TP53LMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |