Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786321 | 0.82 | TP53 (0.44) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2788089 | 0.80 | SMN1; SMN2 (0.46) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2787333 | 0.78 | SMN1; SMN2 (0.45) | TP53SMN1; SMN2ALOX15KMT2AALDH1A1 | |
| SCHEMBL2784919 | 0.77 | SMN1; SMN2 (0.56) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2787441 | 0.75 | TP53 (0.47) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2785764 | 0.75 | ABCC9 (0.45) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2785392 | 0.75 | MAPT (0.42) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2786470 | 0.73 | HTR3A (0.44) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2784590 | 0.73 | TP53 (0.40) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2439515 | 0.73 | TP53 (0.48) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |