Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | HMGCR | P04035 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | TST | Q16762 | 1/20 | 0.52 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257929 | 0.79 | PTPN1 (0.51) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL28090068 | 0.79 | TDP1 (0.47) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL4873777 | 0.78 | MAPT (0.40) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL18197055 | 0.78 | TMPRSS2 (0.73) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL2603151 | 0.78 | TMPRSS2 (0.73) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL22130786 | 0.78 | TMPRSS2 (0.73) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL10182003 | 0.76 | MAPT (0.50) | USP2CA1CA2MAPK1L3MBTL1 | |
| SCHEMBL22130787 | 0.76 | L3MBTL1 (0.64) | TMPRSS2USP2PDE5ACA1CA2 | |
| SCHEMBL4625578 | 0.74 | MAPT (0.50) | USP2CA1CA2MAPK1PTPN1 | |
| Pentagalloyl Glucose SCHEMBL23484369 | 0.73 | USP2 (0.86) | TMPRSS2USP2PDE5ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292157-A1 | Combination Treatments for Alzheimer's Disease and Similar Diseases | WARATAH PHARMACEUTICALS INC. (CA) | 2010-11-18 | — | — | US | disclosed |
| EP-2091566-A1 | COMBINATION TREATMENTS FOR ALZHEIMER'S DISEASE AND SIMILAR DISEASES | Waratah Pharmaceuticals, Inc. (CA) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008061373-A1 | COMBINATION TREATMENTS FOR ALZHEIMER'S DISEASE AND SIMILAR DISEASES | WARATAH PHARMACEUTICALS INC. (CA) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007130383-A2 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND SECRETASES | NORTHWESTERN UNIVERSITY (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292157-A1 | Combination Treatments for Alzheimer's Disease and Similar Diseases | APP, PSEN1, BACE1 | TMPRSS2 563/4885USP2 352/4885PDE5A 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.