Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744175 | 0.84 | ROCK2 (0.45) | HTTGAAMAPTMEN1KMT2A | |
| SCHEMBL27873312 | 0.83 | OPRM1 (0.53) | OPRM1OPRK1MAPTPARP1SMO | |
| SCHEMBL2744172 | 0.82 | HTT (0.43) | HTTGAAMAPTMEN1KMT2A | |
| SCHEMBL27889644 | 0.79 | OPRM1 (0.70) | OPRM1OPRK1MAPTPARP1SMO | |
| SCHEMBL27873250 | 0.78 | OPRM1 (0.63) | OPRM1OPRK1SMOALDH1A1KDM4E | |
| SCHEMBL27739911 | 0.76 | OPRM1 (0.71) | OPRM1OPRK1GAAMAPTPARP1 | |
| SCHEMBL27889571 | 0.75 | OPRM1 (0.58) | OPRM1OPRK1MAPTPARP1SMO | |
| SCHEMBL14193918 | 0.74 | MEN1 (0.52) | HTTGAAMAPTMEN1KMT2A | |
| SCHEMBL27739959 | 0.73 | OPRM1 (0.57) | OPRM1OPRK1SMOHRH3AOC3 | |
| SCHEMBL2828056 | 0.72 | OPRM1 (0.60) | OPRM1OPRK1GAAPARP1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103736094-A | Methods and compositions for treating leukemia | NOVARTIS AG | 2014-04-23 | — | — | CN | disclosed |
| CN-102695547-A | Methods and compositions for treating leukemia | NOVARTIS AG | 2012-09-26 | — | — | CN | disclosed |