Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.62 |
| ▸ | DDO | Q99489 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 5/20 | 0.40 |
| ▸ | IL2 | P60568 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670793 | 0.78 | DAO (0.56) | DAODDOFLT3HRH4ALB | |
| SCHEMBL3363456 | 0.77 | DAO (1.00) | DAODDOFLT3HRH4MAPT | |
| SCHEMBL3632451 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL30605955 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4MEN1 | |
| SCHEMBL4692767 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4MEN1 | |
| SCHEMBL25142137 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL20005057 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL15951255 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL28813362 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL27739684 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389624-B | 3-pyrrolocyclohexylidene-2-indolinone derivative and application thereof | JIANGSU SIMCERE PHARM RES CO | 2012-10-03 | — | — | CN | disclosed |
| CN-102702068-A | 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative, and application of 3-pyrrolo-cyclohexylidene-2-dihydroindolone derivative | JIANGSU SIMCERE PHARM RES CO | 2012-10-03 | — | — | CN | disclosed |