Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.53 |
| ▸ | DDO | Q99489 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 5/20 | 0.39 |
| ▸ | IL2 | P60568 | 5/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670793 | 0.78 | DAO (0.56) | DAODDOFLT3HRH4ALB | |
| SCHEMBL12778107 | 0.75 | IMPDH2 (0.47) | DAODDOHRH4MAPTALDH1A1 | |
| SCHEMBL21356683 | 0.75 | AHR (0.45) | FLT3HRH4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL31070422 | 0.75 | AHR (0.45) | FLT3HRH4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15951255 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL25142137 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL12777898 | 0.75 | ALDH1A1 (0.42) | HRH4KMT2ANPC1LMNARAB9A | |
| SCHEMBL12777913 | 0.75 | ALDH1A1 (0.36) | DAODDOSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL28813362 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4ALB | |
| SCHEMBL30605955 | 0.75 | DAO (0.53) | DAODDOFLT3HRH4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114835625-A | Synthesis method of axial chiral indole derivative containing 2-thiocyano-3-aryl | 泽升科技(广州)有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2018055316-A1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-03-29 | — | — | WO | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-105218565-A | Spiral shell oxindole compounds and the purposes as therapeutical agent thereof | XENON PHARMACEUTICALS INC | 2016-01-06 | — | — | CN | disclosed |
| CN-105175433-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-12-23 | — | — | CN | disclosed |
| CN-103664973-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-03-26 | — | — | CN | disclosed |