Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 2/20 | 0.69 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135531 | 0.82 | AGBL2 (0.71) | AGBL2GLASMN1; SMN2POLQALDH1A1 | |
| SCHEMBL30716956 | 0.82 | AGBL2 (0.71) | AGBL2GLASMN1; SMN2POLQALDH1A1 | |
| SCHEMBL12698841 | 0.82 | AGBL2 (1.00) | AGBL2GLASMN1; SMN2POLQALDH1A1 | |
| SCHEMBL27716277 | 0.81 | AGBL2 (0.69) | AGBL2GLASMN1; SMN2ALDH1A1HPGD | |
| Water SCHEMBL31648404 | 0.78 | AGBL2 (0.66) | AGBL2GLASMN1; SMN2POLQALDH1A1 | |
| SCHEMBL27956188 | 0.75 | AGBL2 (0.44) | AGBL2GLAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2373055 | 0.75 | CFTR (0.55) | AGBL2CFTRGLASMN1; SMN2ALDH1A1 | |
| SCHEMBL21433001 | 0.73 | AGBL2 (0.44) | AGBL2CFTRSMN1; SMN2POLQALDH1A1 | |
| SCHEMBL28813259 | 0.72 | L3MBTL1 (0.40) | AGBL2CFTRSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL27305171 | 0.72 | KMT2A (0.40) | AGBL2CFTRSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103946221-A | Heterocyclic compounds for the treatment of cystic fibrosis | NOVARTIS AG | 2014-07-23 | — | — | CN | disclosed |
| CN-102892758-A | Pyridine and pyrazine derivatives for the treatment of CF | NOVARTIS AG | 2013-01-23 | — | — | CN | disclosed |