Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788972 | 1.00 | MEN1 (0.41) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL20284653 | 0.81 | GPR119 (0.43) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL20284451 | 0.81 | GPR119 (0.45) | MEN1ALDH1A1MAPTKMT2AALOX5AP | |
| SCHEMBL2792024 | 0.79 | GPR119 (0.43) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL2792027 | 0.79 | GPR119 (0.43) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL20284097 | 0.79 | GPR119 (0.43) | MEN1ALDH1A1MAPTKMT2AALOX5AP | |
| SCHEMBL2793629 | 0.78 | BACE1 (0.40) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL2793627 | 0.78 | BACE1 (0.40) | MEN1ALDH1A1MAPTKMT2AJAK2 | |
| SCHEMBL22285792 | 0.77 | GPR119 (0.41) | GPR119USP30 | |
| SCHEMBL29774321 | 0.77 | GPR119 (0.41) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |