Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20284097 | 0.92 | GPR119 (0.43) | GPR119CYP2C9ALOX5APFEN1MEN1 | |
| SCHEMBL2793627 | 0.83 | BACE1 (0.40) | GPR119CYP2C9ALOX5APFEN1MEN1 | |
| SCHEMBL2793629 | 0.83 | BACE1 (0.40) | GPR119CYP2C9ALOX5APFEN1MEN1 | |
| SCHEMBL2792027 | 0.82 | GPR119 (0.43) | GPR119ALOX5APFEN1MEN1ALDH1A1 | |
| SCHEMBL2792024 | 0.82 | GPR119 (0.43) | GPR119ALOX5APFEN1MEN1ALDH1A1 | |
| SCHEMBL7903139 | 0.82 | PIK3CA (0.41) | GPR119CYP2C9ALOX5APFEN1MEN1 | |
| SCHEMBL2788975 | 0.81 | MEN1 (0.41) | GPR119ALOX5APFEN1MEN1ALDH1A1 | |
| SCHEMBL2788972 | 0.81 | MEN1 (0.41) | GPR119ALOX5APFEN1MEN1ALDH1A1 | |
| SCHEMBL20284653 | 0.80 | GPR119 (0.43) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL2789087 | 0.78 | ALOX5AP (0.39) | GPR119ALOX5APFEN1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018109198-A1 | BICYCLIC OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |