Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28922055 | 0.71 | LMNA (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL28645329 | 0.69 | LMNA (0.31) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL28635010 | 0.67 | AOC1 (0.31) | — | |
| SCHEMBL29892102 | 0.65 | LMNA (0.35) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL14677148 | 0.64 | LMNA (0.32) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL31674482 | 0.62 | MAPT (0.37) | — | |
| SCHEMBL14834067 | 0.61 | CA1 (0.39) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3990465 | 0.61 | CA1 (0.34) | — | |
| SCHEMBL3917158 | 0.61 | HTT (0.32) | — | |
| SCHEMBL28260420 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108774237-A | New tricyclic compound | ABBVIE 公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | disclosed |
| CN-102711476-A | Novel tricyclic compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |