Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789086 | 1.00 | ALOX5AP (0.39) | ALOX5APFEN1PIK3CDPIK3CAMEN1 | |
| SCHEMBL7903139 | 0.81 | PIK3CA (0.41) | ALOX5APFEN1PIK3CDPIK3CAMEN1 | |
| SCHEMBL2793629 | 0.79 | BACE1 (0.40) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL2793627 | 0.79 | BACE1 (0.40) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL20284451 | 0.78 | GPR119 (0.45) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL20284097 | 0.78 | GPR119 (0.43) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL16041337 | 0.77 | MEN1 (0.39) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL31652058 | 0.76 | USP30 (0.45) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL2792024 | 0.76 | GPR119 (0.43) | ALOX5APFEN1MEN1ALDH1A1MAPT | |
| SCHEMBL2792027 | 0.76 | GPR119 (0.43) | ALOX5APFEN1MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |