Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL27891030 | 0.97 | MAPT (0.35) | ALDH1A1CYP3A4HPGDEHMT2HSD17B10 | |
| SCHEMBL457988 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL3884637 | 0.75 | — | — | |
| SCHEMBL28873827 | 0.75 | — | — | |
| Piperazine SCHEMBL4778411 | 0.75 | MAPT (0.50) | ALDH1A1NOS2HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL1613092 | 0.75 | MAPT (0.50) | ALDH1A1NOS2HIF1AMAPTPDE4A | |
| Formaldehyde SCHEMBL10946288 | 0.72 | — | — | |
| Piperazine SCHEMBL6371041 | 0.72 | LMNA (0.46) | ALDH1A1NOS2HIF1AMAPTPDE4A | |
| Piperazine SCHEMBL250578 | 0.72 | ACHE (0.54) | ALDH1A1NOS2HIF1AMAPTPDE4A | |
| Bicarbonate SCHEMBL28680773 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102702198-B | Caffeine methylated mother liquor cleaning process and device thereof | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2014-05-28 | — | — | CN | disclosed |
| CN-102702198-A | Caffeine methylated mother liquor cleaning process and device thereof | UNIV QINGDAO SCIENCE & TECHNOLOGY | 2012-10-03 | — | — | CN | disclosed |