Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788260 | 0.88 | NUDT1 (0.46) | NUDT1NPC1MAPK1EGLN2JAK1 | |
| SCHEMBL2788322 | 0.80 | NUDT1 (0.50) | NUDT1MAPK1EGLN2JAK1CDC7 | |
| SCHEMBL1283115 | 0.69 | ADORA2A (0.38) | NUDT1NPC1 | |
| SCHEMBL1282560 | 0.65 | ADORA2A (0.35) | NUDT1 | |
| SCHEMBL2250437 | 0.63 | NUDT1 (0.57) | NUDT1MAPK1EGLN2JAK1PDE10A | |
| SCHEMBL24656050 | 0.62 | NUDT1 (0.59) | NUDT1NPC1EGLN2JAK1 | |
| SCHEMBL2253273 | 0.62 | NUDT1 (0.60) | NUDT1EGLN2JAK1PDE10A | |
| SCHEMBL2254109 | 0.62 | NUDT1 (0.60) | NUDT1EGLN2JAK1PDE10A | |
| SCHEMBL21306411 | 0.61 | L3MBTL1 (0.41) | MAPK1PDE10A | |
| SCHEMBL12145724 | 0.61 | SMN1; SMN2 (0.49) | MAPK1EGLN2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181112-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | Merck Serono S.A. (CH) | 2010-05-05 | — | — | EP | claimed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | claimed |
| EP-2181112-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | Merck Serono S.A. (CH) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | disclosed |