Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | TNKS | O95271 | 14/20 | 0.66 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.66 |
| ▸ | PARP1 | P09874 | 6/20 | 0.66 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.62 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.61 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.59 |
| ▸ | WNT3A | P56704 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893290 | 0.85 | GUSB (0.67) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL16007866 | 0.85 | GUSB (1.00) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL348123 | 0.84 | GUSB (0.66) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL6885282 | 0.84 | TNKS (0.93) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL11832038 | 0.82 | TNKS (0.71) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL30485713 | 0.82 | TNKS (0.71) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL62491 | 0.81 | RAB9A (0.62) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL6124189 | 0.81 | TNKS (0.93) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL29592833 | 0.81 | TNKS (1.00) | GUSBNPC1RAB9AMAPTKDM4E | |
| SCHEMBL258433 | 0.81 | TNKS (1.00) | GUSBNPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102757661-B | Preparation method and application of 4-chloro-2-substituted quinazolone | CONNECT WILSON PENGLAI CHEMICAL CO LTD | 2014-08-27 | — | — | CN | disclosed |
| CN-102757661-A | Preparation method and application of 4-chloro-2-substituted quinazolone | CONNECT WILSON PENGLAI CHEMICAL CO LTD | 2012-10-31 | — | — | CN | disclosed |