Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27894381 | 0.82 | PRMT1 (0.57) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL27319007 | 0.81 | PTGER4 (0.44) | PRMT1PTGER4HRH3HTR4 | |
| SCHEMBL14804765 | 0.80 | KDM4E (0.71) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL3436249 | 0.79 | PRMT1 (0.68) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL10049116 | 0.79 | KDM4E (0.73) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL24478835 | 0.78 | PRMT1 (1.00) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL31616016 | 0.71 | PRMT1 (0.57) | PRMT1SIRT2SIRT1SIRT3NPC1 | |
| SCHEMBL27911632 | 0.70 | KCNJ1 (0.45) | NPC1KDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL28290347 | 0.70 | HRH3 (0.46) | PRMT1KDM4ESMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL27791208 | 0.69 | KDM4E (0.68) | PRMT1NPC1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753858-B | Heterocyclic compound and p27Kip1Decomposing inhibitor | ASKA制药株式会社 | 2019-04-30 | — | — | CN | disclosed |
| CN-105753858-A | Heterocyclic compound and p27Kip1 degradation inhibitor | ASKA制药株式会社 | 2016-07-13 | — | — | CN | disclosed |
| CN-102985405-B | Heterocyclic compounds and p27Kip1Decomposition inhibitor | ASKA制药株式会社 | 2016-07-06 | — | — | CN | disclosed |
| CN-102985405-A | Heterocyclic compounds and p27Kip1Decomposition inhibitor | ASKA PHARM CO LTD | 2013-03-20 | — | — | CN | disclosed |