Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.39 |
| ▸ | HTR2B | P41595 | 6/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676477 | 0.83 | NOS1 (0.51) | NOS1NOS2NOS3ATM | |
| SCHEMBL2675967 | 0.81 | NOS1 (0.52) | HTR2CHTR2BNOS1NOS2NOS3 | |
| SCHEMBL2675463 | 0.80 | NOS1 (0.53) | HTR2CHTR2BNOS1NOS2NOS3 | |
| SCHEMBL2675961 | 0.76 | NOS1 (0.48) | HTR2CHTR2BNOS1NOS2NOS3 | |
| SCHEMBL28837930 | 0.75 | PNMT (0.50) | HTR2CHTR2BPNMTASIC3HTR2A | |
| SCHEMBL2789451 | 0.74 | NOS1 (0.36) | HTR2CHTR2BNOS1NOS2HTR2A | |
| SCHEMBL2676037 | 0.73 | NOS1 (0.49) | HTR2CHTR2BNOS1NOS2NOS3 | |
| SCHEMBL2675880 | 0.72 | NOS1 (0.50) | HTR2CHTR2BNOS1NOS2NOS3 | |
| SCHEMBL24187328 | 0.72 | HTR2C (0.57) | HTR2CHTR2BHTR2A | |
| SCHEMBL2710981 | 0.69 | HTR2C (0.56) | HTR2CHTR2BNOS1NOS2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |