Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720823 | 0.78 | KIF11 (0.38) | PTGS1GABRA1SIGMAR1PTGS2KIF11 | |
| SCHEMBL3559641 | 0.77 | KIF11 (0.51) | PTGS2KIF11APPDAOPDE2A | |
| SCHEMBL29417764 | 0.77 | KIF11 (0.51) | PTGS2KIF11APPDAOPDE2A | |
| SCHEMBL1720610 | 0.76 | NPFFR2 (0.53) | — | |
| SCHEMBL3560692 | 0.76 | IAPP (0.51) | PTGS1APP | |
| SCHEMBL3560696 | 0.76 | IAPP (0.51) | PTGS1APP | |
| SCHEMBL564461 | 0.75 | GABRA1 (0.57) | PTGS1GABRA1SIGMAR1PTGS2ALOX5 | |
| SCHEMBL171048 | 0.72 | TP53 (0.48) | PTGS1PTGS2ALOX5 | |
| SCHEMBL3894458 | 0.71 | APP (0.47) | APP | |
| SCHEMBL6030726 | 0.71 | APP (0.47) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102803210-A | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2012-11-28 | — | — | CN | claimed |
| CN-102803210-A | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV | 2012-11-28 | — | — | CN | disclosed |