Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790303 | 0.98 | PROKR1 (0.40) | PROKR1CNR2HTR4F2REPHX2 | |
| SCHEMBL2790302 | 0.98 | PROKR1 (0.40) | PROKR1CNR2HTR4F2REPHX2 | |
| SCHEMBL2792613 | 0.97 | PROKR1 (0.40) | PROKR1CNR2HTR4F2REPHX2 | |
| SCHEMBL2792611 | 0.97 | PROKR1 (0.40) | PROKR1CNR2HTR4F2REPHX2 | |
| SCHEMBL2790206 | 0.94 | PROKR1 (0.42) | PROKR1CNR2HTR4F2RPER2 | |
| SCHEMBL2790692 | 0.94 | PROKR1 (0.42) | PROKR1CNR2HTR4F2RPER2 | |
| SCHEMBL2790078 | 0.92 | PROKR1 (0.43) | PROKR1CNR2HTR4F2RPER2 | |
| SCHEMBL2791208 | 0.92 | PROKR1 (0.41) | PROKR1CNR2HTR4PER2CRY1 | |
| SCHEMBL2790426 | 0.92 | PROKR1 (0.42) | PROKR1CNR2HTR4PER2CRY1 | |
| SCHEMBL2790427 | 0.92 | PROKR1 (0.42) | PROKR1CNR2HTR4PER2CRY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |