Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790303 | 1.00 | PROKR1 (0.40) | PROKR1CNR2EPHX2ADRB1ADRB3 | |
| SCHEMBL2792613 | 0.99 | PROKR1 (0.40) | PROKR1CNR2EPHX2ADRB1ADRB3 | |
| SCHEMBL2792611 | 0.99 | PROKR1 (0.40) | PROKR1CNR2EPHX2ADRB1ADRB3 | |
| SCHEMBL2789741 | 0.98 | PROKR1 (0.41) | PROKR1CNR2EPHX2ADRB1ADRB3 | |
| SCHEMBL2790206 | 0.93 | PROKR1 (0.42) | PROKR1CNR2HTR4MEN1KMT2A | |
| SCHEMBL2790692 | 0.93 | PROKR1 (0.42) | PROKR1CNR2HTR4MEN1KMT2A | |
| SCHEMBL2790078 | 0.92 | PROKR1 (0.43) | PROKR1CNR2HTR4KMT2ANPC1 | |
| SCHEMBL2790426 | 0.91 | PROKR1 (0.42) | PROKR1CNR2HTR4MEN1KMT2A | |
| SCHEMBL2791208 | 0.91 | PROKR1 (0.41) | PROKR1CNR2HTR4MEN1KMT2A | |
| SCHEMBL2790427 | 0.91 | PROKR1 (0.42) | PROKR1CNR2HTR4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |