Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28650787 | 0.87 | TSHR (0.75) | TSHRAKR1B1ALDH1A1KMT2APOLB | |
| Acetoacetic Acid SCHEMBL11062529 | 0.85 | TSHR (0.54) | TSHRAKR1B1ALDH1A1KMT2APOLB | |
| Acetic Acid SCHEMBL7836902 | 0.83 | TSHR (0.68) | TSHRAKR1B1ALDH1A1KMT2APOLB | |
| Butyric Acid SCHEMBL28664820 | 0.81 | TSHR (0.54) | TSHRAKR1B1ALDH1A1CES2CES1 | |
| Benzene SCHEMBL27633873 | 0.79 | TSHR (0.88) | TSHRALDH1A1PNMTNR4A2 | |
| Maleic Acid SCHEMBL7194412 | 0.79 | TSHR (0.62) | TSHRALDH1A1POLBRECQLCES2 | |
| Fumaric Acid SCHEMBL742919 | 0.79 | TSHR (0.62) | TSHRALDH1A1POLBRECQLCES2 | |
| SCHEMBL25495 | 0.79 | — | — | |
| SCHEMBL29472208 | 0.79 | — | — | |
| Malic Acid SCHEMBL1458964 | 0.78 | SMN1; SMN2 (0.50) | TSHRAKR1B1ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102834174-B | Supported metal catalysts | 约翰逊马西有限公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-102834174-A | Supported metal catalysts | JOHNSON MATTHEY PLC | 2012-12-19 | — | — | CN | disclosed |