Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7836902 | 0.91 | TSHR (0.68) | TSHRALDH1A1CES2CES1POLB | |
| Benzene SCHEMBL27633873 | 0.87 | TSHR (0.88) | TSHRALDH1A1NR4A2LMNACYP3A4 | |
| Glycine SCHEMBL27900643 | 0.87 | TSHR (0.62) | TSHRALDH1A1CES2CES1POLB | |
| Maleic Acid SCHEMBL7194412 | 0.87 | TSHR (0.62) | TSHRALDH1A1CES2CES1POLB | |
| Fumaric Acid SCHEMBL742919 | 0.87 | TSHR (0.62) | TSHRALDH1A1CES2CES1POLB | |
| SCHEMBL29472208 | 0.87 | — | — | |
| SCHEMBL25495 | 0.87 | — | — | |
| Formaldehyde SCHEMBL6858464 | 0.84 | TSHR (0.83) | TSHRALDH1A1CES2CES1RECQL | |
| Methyl Alcohol SCHEMBL27890061 | 0.84 | TSHR (0.83) | TSHRALDH1A1CES2CES1RECQL | |
| Ammonia Solution, Strong SCHEMBL10464135 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113548972-A | Production process of 3, 3' -dichlorobenzidine hydrochloride | 济宁祥泰和新材料科技有限公司 | 2021-10-26 | — | — | CN | disclosed |