Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 6/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27900698 | 1.00 | ACVR1 (0.36) | ACVR1BMPR1AACVRL1TGFBR1BMPR1B | |
| SCHEMBL27900709 | 0.89 | BMPR1A (0.36) | ACVR1BMPR1AACVRL1TGFBR1BMPR1B | |
| SCHEMBL27900710 | 0.89 | BMPR1A (0.36) | ACVR1BMPR1AACVRL1TGFBR1BMPR1B | |
| SCHEMBL985996 | 0.87 | SPHK1 (0.44) | — | |
| SCHEMBL985994 | 0.87 | SPHK1 (0.44) | — | |
| SCHEMBL27900749 | 0.87 | LRRK2 (0.41) | P2RX7LRRK2KCNN4 | |
| SCHEMBL28805617 | 0.86 | LRRK2 (0.37) | P2RX7LRRK2MET | |
| SCHEMBL983307 | 0.85 | MET (0.44) | LRRK2MET | |
| SCHEMBL982530 | 0.85 | SPHK1 (0.44) | ACVR1BMPR1AACVRL1TGFBR1BMPR1B | |
| SCHEMBL983306 | 0.85 | MET (0.44) | LRRK2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479255-B | C-MET protein kinase inhibitors for the treatment of proliferative disorders | VERTEX PHARMA | 2013-05-01 | — | — | CN | claimed |