Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742755 | 0.89 | HRH1 (0.39) | HDAC4PROKR1 | |
| SCHEMBL742754 | 0.89 | HRH1 (0.39) | HDAC4PROKR1 | |
| SCHEMBL7901834 | 0.87 | PROKR1 (0.39) | PROKR1CNR2DPP4DPP9 | |
| SCHEMBL740111 | 0.86 | CFD (0.34) | HDAC4SYKGRM5DPP4DPP9 | |
| SCHEMBL740110 | 0.86 | CFD (0.34) | HDAC4SYKGRM5DPP4DPP9 | |
| SCHEMBL2789838 | 0.85 | PROKR1 (0.37) | PROKR1CNR2RORCDPP4DPP9 | |
| SCHEMBL7898489 | 0.85 | DPP4 (0.38) | PROKR1CNR2RORCDPP4DPP9 | |
| SCHEMBL7902499 | 0.84 | PROKR1 (0.37) | PROKR1CNR2DPP4DPP9 | |
| SCHEMBL2792434 | 0.84 | PROKR1 (0.40) | PROKR1CNR2DPP4DPP9 | |
| SCHEMBL7892716 | 0.84 | PROKR1 (0.39) | PROKR1CNR2DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |