Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740110 | 1.00 | CFD (0.34) | CFDSYKPDCD1CD274KDM1A | |
| SCHEMBL763705 | 0.93 | SYK (0.34) | CFDSYKPDCD1CD274KDM1A | |
| SCHEMBL739094 | 0.93 | CFD (0.35) | CFDPDCD1CD274HRH1CYP2D6 | |
| SCHEMBL739093 | 0.93 | CFD (0.35) | CFDPDCD1CD274HRH1CYP2D6 | |
| SCHEMBL742755 | 0.90 | HRH1 (0.39) | HDAC4HRH1CYP2D6PIK3CDPIK3CB | |
| SCHEMBL742754 | 0.90 | HRH1 (0.39) | HDAC4HRH1CYP2D6PIK3CDPIK3CB | |
| SCHEMBL741288 | 0.90 | CFD (0.36) | CFDHRH1CYP2D6ALDH1A1TSHR | |
| SCHEMBL741289 | 0.90 | CFD (0.36) | CFDHRH1CYP2D6ALDH1A1TSHR | |
| SCHEMBL741981 | 0.88 | CFD (0.35) | CFDHRH1CYP2D6ALDH1A1TSHR | |
| SCHEMBL741982 | 0.88 | CFD (0.35) | CFDHRH1CYP2D6ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |