Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 18/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801589 | 0.77 | ALDH1A1 (0.47) | — | |
| SCHEMBL2790568 | 0.77 | NR2E1 (0.57) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7799638 | 0.77 | NR2E1 (0.47) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27970714 | 0.76 | ALDH1A1 (0.50) | NR2E1 | |
| SCHEMBL13261062 | 0.76 | NR2E1 (1.00) | NR2E1 | |
| SCHEMBL2788631 | 0.75 | NR2E1 (0.45) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1927257 | 0.69 | NR2E1 (0.84) | NR2E1 | |
| SCHEMBL31729830 | 0.68 | NR2E1 (0.74) | NR2E1 | |
| SCHEMBL972166 | 0.68 | NR2E1 (0.47) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17134906 | 0.68 | NR2E1 (0.62) | NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |