Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 12/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13361920 | 0.82 | PSEN1 (0.49) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2790568 | 0.80 | NR2E1 (0.57) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2788631 | 0.78 | NR2E1 (0.45) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2790210 | 0.77 | NR2E1 (0.61) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12361914 | 0.72 | NR2E1 (0.64) | NR2E1 | |
| SCHEMBL3323753 | 0.68 | NR2E1 (0.46) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13361926 | 0.68 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3329200 | 0.68 | NR2E1 (0.54) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28847364 | 0.67 | NR2E1 (0.47) | NR2E1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22745472 | 0.67 | NR2E1 (0.60) | NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |