Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12425116 | 1.00 | GLS (0.49) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL18508122 | 0.92 | GLS (0.58) | GLSEPHX1NR1H2HPGDMEN1 | |
| SCHEMBL7445355 | 0.92 | GLS (0.55) | GLSKDM4EPKMEPHX1HPGD | |
| SCHEMBL2300227 | 0.88 | NR1H2 (0.51) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL15372980 | 0.87 | GLS (0.50) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL31324694 | 0.84 | NR1H2 (0.47) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL6526761 | 0.84 | NR1H2 (0.47) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL31472925 | 0.84 | NR1H2 (0.47) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL20565243 | 0.83 | KDM4E (0.47) | GLSKDM4EPKMEPHX1NR1H2 | |
| SCHEMBL852498 | 0.83 | KDM4E (0.47) | GLSKDM4EPKMEPHX1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102858175-A | Triazolones as fatty acid synthase inhibitors | GLAXOSMITHKLINE LLC | 2013-01-02 | — | — | CN | disclosed |