Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894446 | 1.00 | PROKR1 (0.35) | PROKR1MMP13DPP4KMT2AMEN1 | |
| SCHEMBL2790244 | 1.00 | PROKR1 (0.35) | PROKR1MMP13DPP4KMT2AMEN1 | |
| SCHEMBL2790204 | 0.90 | DPP4 (0.32) | PROKR1DPP4KMT2ACFDALDH1A1 | |
| SCHEMBL2790207 | 0.90 | DPP4 (0.32) | PROKR1DPP4KMT2ACFDALDH1A1 | |
| SCHEMBL2813695 | 0.90 | PROKR1 (0.43) | PROKR1MMP13DPP4KMT2AMEN1 | |
| SCHEMBL2787940 | 0.90 | DPP4 (0.33) | PROKR1DPP4KMT2ACFDALDH1A1 | |
| SCHEMBL7893421 | 0.90 | ACKR3 (0.33) | PROKR1DPP4KMT2ACFDALDH1A1 | |
| SCHEMBL2787942 | 0.90 | DPP4 (0.33) | PROKR1DPP4KMT2ACFDALDH1A1 | |
| SCHEMBL7900593 | 0.89 | PROKR1 (0.35) | PROKR1MMP13DPP4KMT2ANPC1 | |
| SCHEMBL2788008 | 0.88 | DPP4 (0.33) | PROKR1DPP4CFDBACE1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |