SCHEMBL27904994

SCHEMBL27904994

c1ccc(-c2ncn(-c3ccc(-n4cncn4)cc3)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 1/20 0.49
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
LMNA P02545 1/20 0.43
CYP2A6 P11509 1/20 0.42
PIM1 P11309 1/20 0.39
FBP1 P09467 1/20 0.38
ROCK1 Q13464 1/20 0.37
PDE2A O00408 1/20 0.36
POLB P06746 1/20 0.36
PTGER1 P34995 1/20 0.35
HPGDS O60760 1/20 0.35
MGLL Q99685 1/20 0.35
CYP11B2 P19099 1/20 0.35
SMYD3 Q9H7B4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2396469 0.83 CYP11B1 (0.44) ALDH1A1KDM4ESMN1; SMN2MGLLCYP11B2
SCHEMBL458419 0.83 NPC1 (0.46) ALDH1A1KDM4ESMN1; SMN2CYP11B2
SCHEMBL11249373 0.81 ALDH1A1 (0.56) MAPK10ALDH1A1KDM4ESMN1; SMN2CYP1A2
SCHEMBL28238356 0.79 ALDH1A1 (0.49) ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2C9
SCHEMBL4549484 0.79 MEN1 (0.43) ALDH1A1KDM4ESMN1; SMN2LMNAPOLB
SCHEMBL1009561 0.77 CYP2A6 (0.64) MAPK10ALDH1A1KDM4ESMN1; SMN2CYP1A2
SCHEMBL28006297 0.75 CYP2A6 (0.62) MAPK10ALDH1A1KDM4ESMN1; SMN2CYP1A2
SCHEMBL27905069 0.75 SMN1; SMN2 (0.72) MAPK10ALDH1A1KDM4ESMN1; SMN2CYP1A2
SCHEMBL28056895 0.75 TAAR1 (0.47) ALDH1A1KDM4ESMN1; SMN2CYP2A6CYP11B2
SCHEMBL17279827 0.75 GRM5 (0.48) ALDH1A1SMN1; SMN2CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103086988-B Phenyl bistriazole compound, and preparation method and application thereof TIANJIN NORMAL UNIVERSITY (CN) 2014-10-29 CN disclosed
CN-103086988-A Phenyl bistriazole compound, and preparation method and application thereof UNIV TIANJIN NORMAL 2013-05-08 CN disclosed