SCHEMBL458419

SCHEMBL458419

c1ccc(-c2ncn(-c3ccccc3)n2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.46
RAB9A P51151 4/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
HPGD P15428 3/20 0.46
TSHR P16473 2/20 0.46
ALOX15 P16050 1/20 0.46
NOTUM Q6P988 1/20 0.45
MAPT P10636 3/20 0.42
ADORA2A P29274 1/20 0.42
ADORA2B P29275 1/20 0.42
ADORA1 P30542 1/20 0.42
GRM5 P41594 2/20 0.41
MAPK1 P28482 1/20 0.41
ALDH1A1 P00352 2/20 0.41
MEN1 O00255 1/20 0.41
ALOX15B O15296 1/20 0.41
KMT2A Q03164 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2396469 0.92 CYP11B1 (0.44) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL17279827 0.90 GRM5 (0.48) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL16073117 0.87 NPC1 (0.47) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL4549484 0.87 MEN1 (0.43) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL6758198 0.87 MEN1 (0.45) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL28238356 0.87 ALDH1A1 (0.49) NPC1RAB9ASMN1; SMN2HPGDMAPT
SCHEMBL6832118 0.84 KCNJ1 (0.44) NPC1RAB9ASMN1; SMN2HPGDTSHR
SCHEMBL4549490 0.84 HPGDS (0.50) NPC1RAB9ASMN1; SMN2HPGDMAPT
SCHEMBL21531807 0.83 OPRD1 (0.47) GRM5MEN1KMT2A
SCHEMBL24209217 0.83 SMN1; SMN2 (0.41) NPC1RAB9ASMN1; SMN2HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4301816-A1 COATING COMPOSITIONS COMPRISING A POLYSULFIDE CORROSION INHIBITOR PRC-Desoto International, Inc. (US) 2024-01-10 EP claimed
CN-117377727-A Coating composition comprising polysulfide corrosion inhibitor PRC-迪索托国际公司 2024-01-09 CN claimed
WO-2022187844-A1 COATING COMPOSITIONS COMPRISING A POLYSULFIDE CORROSION INHIBITOR PRC-DESOTO INTERNATIONAL, INC. (US) 2022-09-09 WO claimed
US-5866653-A FINE POWDERY SILICA; A REACTION MIXTURE OF (A) A PLATINUM COMPOUND AND (B) A COMPOUND CONTAINING AN ALKYNYL GROUP AND AN ALCOHOLIC HYDROXY GROUP IN EACH MOLECULE; AND A CURING AGENT. DOW CORNING TORAY SILICONE CO., LTD. (JP) 1999-02-02 US claimed
US-5646198-A MIXTURE INCLUDES POLYMER, BENZOTRIAZOLE OR TRIAZOLE COMPOUND, AND COMPOUND WITH HYDROPHOBIC AND HYDROPHILIC PARTS; STORAGE STABILITY; MARINE STRUCTURES HITACHI CHEMICAL COMPANY, LTD. (JP) 1997-07-08 US claimed
US-5104919-A With curing retardant or flame retardant triazole compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-04-14 US claimed
US-12630740-B2 Compositions containing thermally conductive fillers PPG INDUSTRIES OHIO, INC. (US) 2026-05-19 US disclosed
US-12577412-B2 Corrosion inhibiting coating compositions PRC-DESOTO INTERNATIONAL, INC. (US) 2026-03-17 US disclosed
EP-4136139-B1 USE OF A COATING FORMED FROM A COMPOSITION CONTAINING THERMALLY CONDUCTIVE FILLERS TO PROVIDE A SUBSTRATE WITH THERMAL AND FIRE PROTECTION PPG IND OHIO INC (US) 2025-08-20 EP disclosed
WO-2025151695-A1 COATING COMPOSITIONS COMPRISING MAGNESIUM OXIDE AND A LITHIUM COMPOUND PRC-DESOTO INTERNATIONAL, INC. (US) 2025-07-17 WO disclosed
WO-2025104108-A1 ADDITION-CROSSLINKABLE LIQUID SILICONE RUBBER COMPOSITION WITH LOW TOTAL VOLATILE CONTENT MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) 2025-05-22 WO disclosed
CN-119739005-A Photosensitive resin composition, photosensitive resin film, method for producing cured product, laminate, and electronic device 株式会社力森诺科 2025-04-01 CN disclosed
EP-4136136-B1 CONTROLLING CURE RATE WITH WETTED FILLER PRC DESOTO INT INC (US) 2025-01-29 EP disclosed
US-5328803-A Alkali developable solutions with carboxy group binders and monomer with initiators FUJI PHOTO FILM CO., LTD. (JP) 1994-07-12 US disclosed
EP-0517524-A1 Roll base-forming composition and fixing roll SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-12-09 EP disclosed
US-5104919-A With curing retardant or flame retardant triazole compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1992-04-14 US disclosed
EP-0388201-A2 Curable silicone composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1990-09-19 EP disclosed
US-4310444-A POLYSILOXANES, SILICA, PLATINUM OR PLATINUM COMPOUND, FATTY ACID OR ITS SALT AND A PEROXIDE TORAY SILICONE COMPANY, LTD. (JP) 1982-01-12 US disclosed
US-4156674-A PLATINUM OR COMPOUND THEREOF, CARBON BLACK AND A TRIAZOLE FOR SELF-EXTINGUISHING CHARACTER, CURING CATALYST AND A SILICON CONTAINING CROSSLINKER TORAY SILICONE COMPANY, LTD. (JP) 1979-05-29 US disclosed
US-4087399-A ORGANO-POLYSILOXANE, SILICA FILLER, PLATINUM, CARBON BLACK, TITANIUM DIOXIDE, AND TRIAZOLE COMPOUND TORAY SILICONE COMPANY, LTD. (JA) 1978-05-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630740-B2 Compositions containing thermally conductive fillers ATP5MK, ITGAM, HNRNPM NPC1 3602/4885RAB9A 3080/4885SMN1; SMN2 1970/4885
US-12577412-B2 Corrosion inhibiting coating compositions MGMT, MBD2, MECP2 NPC1 3972/4885RAB9A 2485/4885SMN1; SMN2 2878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.