Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.44 |
| ▸ | FER | P16591 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | HCK | P08631 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | LTK | P29376 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.44 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.44 |
| ▸ | STK3 | Q13188 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064616 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL4065548 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL4064611 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL4065551 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL7020150 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL4064618 | 0.82 | ALDH1A1 (0.51) | SYKFERJAK2ROCK2MAP4K4 | |
| SCHEMBL11496595 | 0.78 | ALDH1A1 (0.47) | SYKFERPIM1LRRK2LMNA | |
| SCHEMBL11499914 | 0.78 | ALDH1A1 (0.47) | SYKFERPIM1LRRK2LMNA | |
| SCHEMBL15928723 | 0.78 | KDM4E (0.48) | ROCK2ROCK1DDB1CRBNKDM4E | |
| SCHEMBL21799663 | 0.77 | KDM4E (0.50) | DDB1CRBNKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102020638-B | 2-indolinone derivative with protein kinase inhibition activity and histone deacetylase inhibition activity and preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2013-05-08 | — | — | CN | disclosed |
| CN-102020607-B | 6-aminoniacinamide derivatives with histone deacetylase inhibiting activity, preparation method and application thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2013-01-23 | — | — | CN | disclosed |