Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27760523 | 0.90 | CYP3A4 (0.35) | ALDH1A1CYP3A4CHRM2CHRM1CHRM3 | |
| SCHEMBL27760446 | 0.90 | CYP3A4 (0.35) | ALDH1A1CYP3A4CHRM2CHRM1CHRM3 | |
| SCHEMBL27760445 | 0.90 | CYP3A4 (0.35) | ALDH1A1CYP3A4CHRM2CHRM1CHRM3 | |
| SCHEMBL27766894 | 0.87 | ALOX5 (0.37) | ALOX5ALDH1A1 | |
| SCHEMBL28181637 | 0.85 | CHRM2 (0.35) | CHRM2CHRM1CHRM3 | |
| SCHEMBL28803663 | 0.85 | CHRM2 (0.35) | CHRM2CHRM1CHRM3 | |
| SCHEMBL27695299 | 0.85 | CHRM2 (0.35) | CHRM2CHRM1CHRM3 | |
| SCHEMBL27879002 | 0.84 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL29851808 | 0.84 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL27993435 | 0.84 | NR1H2 (0.35) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105254624-A | Isothiazole derivative PIM kinase inhibitor and preparation method thereof, and application of inhibitor in pharmacy | SHANGHAI JIKAI MEDICAL TECHNOLOGY CO LTD | 2016-01-20 | — | — | CN | disclosed |
| CN-105218523-A | Pyridine derivate PIM kinase inhibitor and preparation method thereof and the application in pharmacy | SHANGHAI JIKAI PHARMACEUTICAL TECHNOLOGY CO LTD | 2016-01-06 | — | — | CN | disclosed |
| CN-105130959-A | PIM (provims integration of maloney) kinase inhibitor adopting pyrimidine derivative structure, preparation method of PIM kinase inhibitor and application of PIM kinase inhibitor to pharmacy | SHANGHAI JIKAI MEDICAL TECHNOLOGY CO LTD | 2015-12-09 | — | — | CN | disclosed |
| CN-102858782-A | 4 - [cycloalkyloxy (hetero) arylamino] thieno [2, 3 - d] pyrimidines having mnkl/ mnk2 inhibiting activity for pharmaceutical compositions | BOEHRINGER INGELHEIM INT | 2013-01-02 | — | — | CN | disclosed |