Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.55 |
| ▸ | SMO | Q99835 | 6/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27889255 | 0.89 | SMN1; SMN2 (0.58) | SMN1; SMN2GRM4CYP11B2LMNARAB9A | |
| SCHEMBL27544662 | 0.81 | GRM4 (0.62) | SMN1; SMN2GRM4CYP11B2LMNARAB9A | |
| SCHEMBL18083728 | 0.80 | KCNK3 (0.53) | LMNAGAA | |
| SCHEMBL27796647 | 0.78 | SMO (0.68) | SMN1; SMN2GRM4LMNARAB9ATP53 | |
| SCHEMBL509115 | 0.77 | KCNQ3 (0.71) | RAB9ANPC1MEN1MAPTKMT2A | |
| SCHEMBL15884251 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNARAB9ATP53NPC1 | |
| SCHEMBL775201 | 0.74 | KCNQ3 (0.58) | SMN1; SMN2LMNARAB9ANPC1GAA | |
| SCHEMBL6300608 | 0.74 | SMO (0.71) | SMN1; SMN2GRM4LMNARAB9ANPC1 | |
| SCHEMBL2117583 | 0.74 | SMO (0.75) | SMN1; SMN2GRM4LMNARAB9ANPC1 | |
| SCHEMBL1900631 | 0.74 | PDE7A (0.41) | SMN1; SMN2RAB9ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102884051-A | Pyrazole compounds as CRTH2 antagonists | BOEHRINGER INGELHEIM INT | 2013-01-16 | — | — | CN | disclosed |