Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28803983 | 0.84 | BMX (0.54) | FLT3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27890747 | 0.81 | FLT3 (0.44) | FLT3MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL27890801 | 0.81 | MAPT (0.55) | MAPTACACAKDM4EALDH1A1LMNA | |
| SCHEMBL28803899 | 0.76 | HTR2C (0.40) | FLT3BMXCYP11B2 | |
| SCHEMBL27907634 | 0.74 | ALDH1A1 (0.46) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL27907531 | 0.74 | HTR2C (0.39) | FLT3BMXCYP11B2 | |
| SCHEMBL27907529 | 0.74 | FUBP1 (0.45) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27907542 | 0.74 | RIPK2 (0.38) | MAPTKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL1890032 | 0.72 | PPARG (0.56) | FLT3ACACARAB9AENPP1CYP1A2 | |
| SCHEMBL13509027 | 0.71 | FLT3 (0.44) | FLT3MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101906105-B | Pyrazolo (1,5-a) pyrimidone derivative as well as drug combination thereof and application thereof | UNIV HEBEI MEDICAL | 2013-01-16 | — | — | CN | disclosed |