Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.60 |
| ▸ | BRAF | P15056 | 13/20 | 0.60 |
| ▸ | FBP1 | P09467 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890908 | 0.87 | RAF1 (0.70) | RAF1BRAFFBP1EGFRKDR | |
| SCHEMBL27907739 | 0.83 | RAF1 (0.66) | RAF1BRAFEGFRKDRERBB2 | |
| SCHEMBL27907895 | 0.83 | RAF1 (0.60) | RAF1BRAFFBP1EGFRKDR | |
| SCHEMBL28801394 | 0.82 | BRAF (0.67) | RAF1BRAFEGFRKDR | |
| SCHEMBL27907697 | 0.81 | EGFR (0.62) | RAF1BRAFEGFRERBB2ALDH1A1 | |
| SCHEMBL17845962 | 0.81 | RAF1 (0.59) | RAF1BRAFFBP1EGFRKDR | |
| SCHEMBL17845938 | 0.80 | KDM4E (0.64) | FBP1MAPTEGFRKDRAURKA | |
| SCHEMBL1734531 | 0.80 | NCOA1 (0.67) | RAF1BRAFFBP1MAPTEGFR | |
| SCHEMBL27986782 | 0.80 | EGFR (0.61) | RAF1BRAFEGFRKDRERBB2 | |
| SCHEMBL1733817 | 0.79 | EGFR (0.60) | RAF1BRAFFBP1MAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | claimed |
| CN-102924387-B | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2015-07-01 | — | — | CN | disclosed |
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | disclosed |